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Severe hypoglycaemia in a person with insulin autoimmune syndrome accompanied by insulin receptor anomaly type B
Author(s) -
Kato T.,
Itoh M.,
Hanashita J.,
Itoi T.,
Matsumoto T.,
Ono Y.,
Imamura S.,
Hayakawa N.,
Suzuki A.,
Mizutani Y.,
Uchigata Y.,
Oda N.
Publication year - 2007
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2007.02232.x
Subject(s) - medicine , insulin , endocrinology , insulin receptor , autoantibody , prednisolone , type 1 diabetes , polyclonal antibodies , antibody , receptor , diabetes mellitus , immunology , insulin resistance
Aims A rare case of the insulin autoimmune syndrome (IAS) accompanied by insulin receptor anomaly is reported. Methods Antibodies to insulin and insulin receptor were determined in the patient with severe hypoglycaemia before and after the treatment with prednisolone. Results Titers of antibody to insulin and insulin receptors were 73.0% and 41.5%, respectively. Drug‐induced lymphocyte stimulation tests were all negative for the suspicious drugs. Her HLA‐DR was DRB1*0403/04051. Following steroid therapy, the formation of antibodies was suppressed and alleviated her symptoms. Scatchard analysis yielded findings specific to polyclonal antibodies. Conclusions The changes in autoantibodies resulted in alleviation of the hypoglycemic symptoms as a result of steroid therapy.