Premium
Plasma endothelin response to acute hypoglycaemia in adults with Type 1 diabetes
Author(s) -
Wright R. J.,
Macleod K. M.,
Perros P.,
Johnston N.,
Webb D. J.,
Frier B. M.
Publication year - 2007
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2007.02199.x
Subject(s) - medicine , endocrinology , endothelin 1 , endothelin receptor , diabetes mellitus , type 2 diabetes , insulin , vasoconstriction , type 1 diabetes , receptor
Aims To determine whether acute insulin‐induced hypoglycaemia provokes a detectable alteration in peripheral plasma endothelin (ET) concentrations in humans with Type 1 diabetes. Methods Serial plasma concentrations of ET were measured in 20 patients with Type 1 diabetes during controlled hypoglycaemia induced by intravenous infusion of soluble insulin. Results A significant increase was observed in plasma ET concentrations, from 3.80 ± 0.31 pg/ml at baseline to 6.72 ± 1.47 pg/ml at 60 min after the onset of the hypoglycaemic reaction ( P < 0.05). Conclusions Acute insulin‐induced hypoglycaemia induces a rise in plasma endothelin concentrations in people with Type 1 diabetes. This finding is consistent with a putative role for ET in the mediation of hypoglycaemia‐induced vasoconstriction, and the possible precipitation of macrovascular or microvascular events.