Premium
Lack of association between polymorphisms in the gene encoding protein tyrosine phosphatase 1B ( PTPN1 ) and risk of Type 2 diabetes
Author(s) -
Wanic K.,
Malecki M. T.,
Klupa T.,
Warram J. H.,
Sieradzki J.,
Krolewski A. S.
Publication year - 2007
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2007.02132.x
Subject(s) - haplotype , single nucleotide polymorphism , medicine , genotype , genetics , genetic association , allele , population , case control study , biology , gene , environmental health
Aims Recently, an association of Type 2 diabetes (T2DM) with polymorphisms in PTPN1 located on chromosome 20q was reported. We attempted to replicate this finding in an ethnically homogeneous Polish population. Methods The study groups comprised 474 cases with T2DM and 411 control subjects with normal fasting glucose. All individuals were genotyped for the five previously reported PTPN1 polymorphisms using a fluorescence polarization method. HAPLO.STAT software was used to infer and compare haplotype distributions. Results The distributions of alleles and genotypes for the five genotyped PTPN1 polymorphisms did not differ between the T2DM cases and control subjects (lowest P = 0.6). Similarly, the frequency of the common haplotype reported to be associated with T2DM did not differ in cases and control subjects. We also failed to find such an association in Whites by performing a meta‐analysis of all the available data on the association of those five SNPs with T2DM. Conclusion This case–control study in a Polish population did not confirm the reported association between polymorphisms in PTPN1 and T2DM.