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History of major depressive disorder and diabetes outcomes in diet‐ and tablet‐treated post‐menopausal women: a case control study
Author(s) -
Wagner J. A.,
Tennen H.
Publication year - 2007
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2007.02044.x
Subject(s) - medicine , major depressive disorder , subclinical infection , depression (economics) , confounding , diabetes mellitus , type 2 diabetes , psychiatry , antidepressant , anxiety , mood , endocrinology , economics , macroeconomics
Abstract Aims Little is known about the long‐term associations between remitted major depressive disorder (MDD) and clinical diabetes outcomes. This study investigated associations between a remote history of fully remitted MDD and (i) glycaemic control, (ii) diabetes symptoms, and (iii) physical and emotional functioning in post‐menopausal women with Type 2 diabetes (T2DM). Methods Forty‐four post‐menopausal women with diet‐ or tablet‐treated T2DM participated. Twenty‐three had never experienced depression and 21 had a history of MDD. All participants had been free of MDD and antidepressant treatment for ≥ 1 year. Results Compared with their never‐depressed counterparts, women with a history of MDD had significantly higher HbA 1c (7.0 vs. 6.5%), more diabetes symptoms, and worse emotional functioning, after controlling for confounding variables. Differences in HbA 1c and diabetes symptoms were not accounted for by the higher current subclinical depressive symptoms observed in the previously depressed group. Differences in emotional functioning were accounted for by current subclinical depressive symptoms. Conclusions Most health‐care providers overlook fully remitted depression. However, previously depressed patients, who outnumber currently depressed patients, may still have poorer glycaemic control than never‐depressed patients.