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Circulating adipocytokines in non‐diabetic and Type 1 diabetic children: relationship to insulin therapy, glycaemic control and pubertal development
Author(s) -
Celi F.,
Bini V.,
Papi F.,
Santilli E.,
Castellani M. S.,
Ferretti A.,
Mencacci M.,
Berioli M. G.,
De Giorgi G.,
Falorni A.
Publication year - 2006
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2006.01823.x
Subject(s) - medicine , adipokine , resistin , endocrinology , adiponectin , leptin , diabetes mellitus , insulin , body mass index , type 1 diabetes , type 2 diabetes mellitus , insulin resistance , obesity
Aim To determine the influence of Type 1 diabetes mellitus on circulating adipocytokines in children. Methods The circulating concentrations of leptin, adiponectin, resistin and tumour necrosis factor (TNF)‐α were measured in 91 children, aged 11.1 ± 2.7 years, with Type 1 diabetes mellitus (T1DM). Ninety‐one healthy children were selected as control subjects. Results Body mass index‐adjusted leptin concentrations were higher in the pubertal diabetic children compared with the control children. There was a significant positive correlation between leptin and daily insulin dose in the diabetic group. Circulating adiponectin concentrations were higher in the prepubertal diabetic children and were positively associated with HbA 1c . Resistin concentrations were lower in the prepubertal non‐diabetic subjects compared with the pubertal non‐diabetic children, whose values were higher than those of the diabetic children. TNF‐α concentrations were similar in non‐diabetic and diabetic children. Conclusions Circulating concentrations of adipocytokines are abnormal in Type 1 diabetic children, although the direction of change differs by cytokine. Pubertal development, in addition to insulin treatment and glycaemic control, also influences the concentrations.