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NT‐proBNP in normoalbuminuric patients with Type 2 diabetes mellitus
Author(s) -
Andersen N. H.,
Poulsen S. H.,
Knudsen S. T.,
Heickendorff L.,
Mogensen C. E.
Publication year - 2005
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2004.01396.x
Subject(s) - medicine , cardiology , ejection fraction , diastole , albuminuria , diabetes mellitus , left ventricular hypertrophy , left atrial enlargement , muscle hypertrophy , type 2 diabetes mellitus , type 1 diabetes , endocrinology , blood pressure , heart failure , atrial fibrillation , sinus rhythm
Objective To examine levels of NT‐proBNP and its relation to hypertension, as well as diastolic function in normoalbuminuric patients with Type 2 diabetes. Research design and methods The study comprised 60 Type 2 diabetic patients without albuminuria. Thirty patients were normotensive and 30 had hypertension. Exclusion criteria were cardiac symptoms and an ejection fraction < 55%. Thirty age‐ and sex‐matched normal subjects served as controls. Diastolic dysfunction was assessed with echocardiography, by means of mitral inflow and colour M‐Mode flow propagation recordings. Results Overall NT‐proBNP was significantly elevated in the Type 2 diabetes group, compared with the controls [54.5 pg/ml (5–162) vs. 32.7 pg/ml (5–74.3) P = 0.02]. NT‐proBNP was significantly higher among hypertensive patients compared with both normotensive patients and controls but no difference was found between the normotensive patients and the controls [58.0 pg/ml (8.5–162), P < 0.05 vs. 50.8 pg/ml (5–131) P = 0.4]. Patients with concentric and eccentric hypertrophy had significantly higher NT‐proBNP levels compared with the control group [81.0 pg/ml (5–147), P < 0.001 and 66.8 pg/ml (42–128), P < 0.001], whereas patients with left ventricular remodelling (enlarged relative wall diameter but normal left ventricular mass) were comparable with the control group [42.3 pg/ml (8.3–142) P = 0.55]. Patients with left atrial enlargement also had incremental NT‐proBNP values. NT‐proBNP was only moderately correlated to age ( r = 0.33, P < 0.05) and left ventricular diastolic diameter ( r = 0.41, P < 0.05), but unrelated to diastolic function. Conclusions NT‐proBNP is significantly increased in hypertensive, normoalbuminuric patients with Type 2 diabetes. These findings were related to left ventricular hypertrophy and increased left atrial and ventricular diameters.