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No nephropathy in Type 2 diabetic patient with POEMS syndrome with an elevated plasma VEGF
Author(s) -
Baba T.,
Østerby R.,
NeugebauerBaba S.,
Nozawa Y.,
Watanabe T.,
Sakurai K.,
Katoh T.,
Watanabe T.
Publication year - 2004
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2004.01094.x
Subject(s) - medicine , diabetic nephropathy , nephropathy , vascular endothelial growth factor , diabetes mellitus , retinopathy , pathogenesis , endocrinology , diabetic retinopathy , poems syndrome , vegf receptors , polyneuropathy
Vascular endothelial growth factor (VEGF) is considered to have a role in the pathogenesis of diabetic retinopathy. Recent experimental observations that anti‐VEGF neutralizing antibody fully abolished the hyperfiltration and the increase in urinary albumin excretion suggested the contribution of VEGF to the development of diabetic nephropathy, as well. Here, we present a case of POEMS (Crow–Fukase) syndrome with Type 2 diabetes, which was associated with elevated plasma VEGF level, but no sign of diabetic nephropathy. The findings obtained from this case did not support the hypothesis that VEGF may enhance the development of diabetic nephropathy.