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Screening for Microalbuminuria in Type 2 Diabetic Patients: the Evaluation of a Dipstick Test in General Practice
Author(s) -
Grauw W.J.C.,
Lisdonk E.H.,
Hoogen H.J.M.,
Gerwen W.H.E.M.,
Bosch W.J.H.M.,
Willems J.L.,
Weel C.
Publication year - 1995
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1995.tb00565.x
Subject(s) - microalbuminuria , medicine , dipstick , nephelometry , urine , receiver operating characteristic , albuminuria , test (biology) , gastroenterology , kidney disease , renal function , paleontology , antibody , immunology , biology
To evaluate the Micral test, a semiquantitative dipstick test, in a general practice setting, 317 Type 2 diabetic patients completed a screening for microalbuminuria by means of the Micral test as well as immuno‐nephelometry with the Disc 120 immuno‐nephelometer (Hyland, Nivelles, Belgium). Data were collected in 10 general practices performing the Nijmegen Monitoring Project. At a regular check‐up each Type 2 diabetic patient was asked to collect first morning urine samples on three consecutive days. The sensitivity of the Micral test was 67 %, the specificity 93 %. Between the practices the sensitivity ranged from 58 % to 81 %, the specificity from 87 % to 95 %. Microalbuminuria, defined as a mean urine albumin concentration ≥ 20 mg l −1 by nephelometry on three consecutive days, was found in 66 patients (21 %). The first Micral test correctly picked out these patients with microalbuminuria in 70 % of the cases and in 90 % those patients without microalbuminuria. The diagnostic performance of the Micral test was further proved by a Receiver Operating Characteristic (ROC) curve. The Area Under the Curve (AUC) of the Micral test was 0.84 (95 % Cl 0.78–0.90). Micral test results of 0 and 10 should be regarded as negative.