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Longitudinal Study of Lipoprotein(a) in Peripubertal Children with Insulin‐dependent Diabetes
Author(s) -
Couper J.J.,
Cocciolone R.,
Bates D.J.,
Nairn J.,
Ryall R.G.
Publication year - 1995
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1995.tb00533.x
Subject(s) - medicine , endocrinology , excretion , lipoprotein , albumin , nephelometry , lipoprotein(a) , insulin , radioimmunoassay , diabetes mellitus , cholesterol , immunology , antibody
We aimed to examine the longitudinal relationship between lipoprotein(a) and haemoglobin A 1c , albumin excretion rate, and puberty in peripubertal children with insulin‐dependent diabetes. A total of 114 patients aged 11.5 ± 3.6 years (mean (SD)) were followed prospectively for 15.2 ± 2.8 months. Lipoprotein(a), apolipoproteinB‐100, haemoglobin A 1c , mean overnight albumin excretion rate and Tanner stage were determined at the beginning and end of the study period. Lipoprotein(a) and apolipoproteinB‐100 were measured using nephelometry. This method was correlated with radioimmunoassay and there was no significant change in mean bias during the study. Lipoprotein(a) fell significantly over time (214, (152, 276); 160 (84, 236) mg I −1 geometric mean (0.95 confidence intervals), p < 0.001); apolipoproteinB‐100 did not change. Lipoprotein(a) and apolipoproteinB‐100 did not differ in 233 cross‐sectional controls of similar age. The change in lipoprotein(a) did not correlate with a small fall in haemoglobin A 1c or with overnight albumin excretion rate, Tanner stage or insulin dose. Separate analysis of male and female patients and prepubertal and pubertal patients continued to show a significant fall in lipoprotein(a) independent of change in haemoglobin A 1c or albumin excretion rate. Likewise, 53 patients with a change in haemoglobin A 1c of greater than 1%, and 20 patients who progressed from normal albumin excretion rate to albumin excretion rate above the 95th centile, showed no relationship between lipoprotein(a) and haemoglobin A 1c or albumin excretion rate. In conclusion, longitudinal changes in lipoprotein(a) do not relate to metabolic control or early changes in albuminuria in young patients with insulin‐dependent diabetes.