Premium
Coagulation Activation in Type 2 Diabetes Mellitus: the Higher Coronary Risk of Female Diabetic Patients
Author(s) -
Chan P.,
Pan W.H.
Publication year - 1995
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1995.tb00532.x
Subject(s) - medicine , partial thromboplastin time , fibrinogen , diabetes mellitus , prothrombin time , risk factor , antithrombin , coagulation , gastroenterology , endocrinology , heparin
Thrombophilia in diabetic patients is a well‐recognized phenomenon which constitutes an additional risk of coronary heart disease. This study included 1980 ethnic Chinese people (835 male, 1145 female); age range: 45 to 69 years, including 280 Type 2 diabetic patients (male 125, female 155). Haemostatic parameters measured were fibrinogen, prothrombin time, activated partial thromboplastin time (APTT), factor VIIc, factor VIIIc, antithrombin III, and plasminogen. Compared with a control group, male diabetic patients showed significantly shorter APTT (25.6 ± 3.7 vs 27.5 ± 3.6 s, p <0.001), and elevated factor VIIIc (171.1 ± 77.48 vs 131.16 ± 52.23%, p <0.0001), whereas female diabetic patients showed significantly shorter APTT (24.9 ± 4.2 vs 26.5 ± 3.9 s, p <0.001) and elevated fibrinogen (10.6 ± 3.3 vs 9.8 ± 2.6 μmol 1 −1 , p <0.05), factor VIIc (150.4 ± 68.7 vs 135.3 ± 32.3%, p <0.001), factor VIIIc (190.1 ± 92.6 vs 141.1 ± 62.4%, p <0.0001), and plasminogen (140.3 ± 41.9 vs 128.4 ± 38.7%, p <0.01). This study showed that Chinese diabetic patients had coagulation activation, and that female diabetic patients seemed to constitute a higher risk group for coronary heart disease than males.