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Raised Ambulatory Blood Pressure in Type 1 Diabetes with Incipient Microalbuminuria
Author(s) -
Page S.R.,
Manning G.,
Ingle A.R.,
Hill P.,
MillarCraig M.W.,
Peacock I.
Publication year - 1994
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1994.tb00372.x
Subject(s) - microalbuminuria , medicine , blood pressure , ambulatory blood pressure , cardiology , diabetes mellitus , ambulatory , endocrinology
Whether raised blood pressure precedes, follows or develops in parallel with the onset of microalbuminuria, remains unclear. Previous studies, using conventional blood pressure recordings, have yielded discrepant results. Ambulatory blood pressure (ABP) monitoring detects borderline hypertension more reliably, and correlates more closely with end‐organ damage. We have therefore compared ABP and left ventricular dimensions in normotensive insulin‐dependent diabetic patients with or without microalbuminuria, and matched non‐diabetic control subjects. Those diabetic patients with microalbuminuria, and to a lesser extent those without, had higher 24 h mean arterial blood pressure than matched non‐diabetic control subjects, with corresponding increases of left ventricular mass, interventricular septal width and posterior wall thickness. These observations suggest that raised arterial blood pressure is present at an early stage of ‘incipient’ microalbuminuria.