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Variations in Sample pH and pO 2 Affect ExacTech Meter Glucose Measurements
Author(s) -
Kilpatrick E.S.,
Rumley A.G.,
Smith E.A.
Publication year - 1994
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1994.tb00315.x
Subject(s) - medicine , affect (linguistics) , glucose meter , metre , sample (material) , diabetes mellitus , endocrinology , chromatography , communication , chemistry , physics , astronomy , sociology
A study was conducted to assess the effect of changes in sample pH and pO 2 on the Accutrend, ExacTech Companion, Glucometer II, One Touch II, and Refloflux II blood glucose meters. Venous blood was tonometered after the addition of strong acid or alkali to produce 10 samples with a pH range of 6.54 to 7.73 but with a similar mean pO 2 (9.09 ± 0.096 (SEM) kPa) and pCO 2 (5.52 ± 0.024 kPa). The ExacTech showed a > 15% deviation from the value obtained at pH 7.40 below pH 6.95 and above pH 7.85 ( r = 0.69, p = 0.026). Ten further samples were made with a pO 2 range of 2.0 to 33.6 kPa but mean pH (7.28 ± 0.012) and pCO 2 (7.98 ± 0.25 kPa) kept alike. The ExacTech was accurate at pO 2 =11.5 kPa but deviated by > 15% below pO 2 = 5.8 kPa and above 22.9 kPa ( r = −0.95, p = 0.00002). The Accutrend and One Touch II required a PO 2 change of 42 and 45 kPa to achieve the same error ( r = ( r 0.82 and r = −0.67 respectively). Thus caution is required in the interpretation of ExacTech glucose measurements in severely acidotic or hypoxic patients.