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Serum Lipids and Apolipoproteins and Their Relationship with Macrovascular Disease in Type 1 Diabetes
Author(s) -
Merrin P.K.,
Renton S.,
Fisher C.,
Henderson A.,
Richmond W.,
Nicholaides A.,
Elkeles R.S.
Publication year - 1994
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1994.tb00293.x
Subject(s) - medicine , macrovascular disease , apolipoprotein b , diabetes mellitus , fibrinogen , cholesterol , endocrinology , type 2 diabetes , type 2 diabetes mellitus , vascular disease , gastroenterology
In order to examine the relationship between serum lipids and apolipoproteins and macrovascular disease in patients with Type 1 diabetes mellitus, 50 patients with Type 1 diabetes mellitus attending the diabetic clinics at St Mary's and St Charles' Hospitals, London were recruited into a cross‐sectional study. B‐mode ultrasound was used to measure intima‐media thickness and define an arterial ultrasound score for each patient as a non‐invasive indicator of atherosclerotic change. Intima‐medial (i‐m) thickness was significantly higher in those subjects with clinical evidence of macrovascular disease compared to those without macrovascular disease (0.865 ± 0.191 vs 0.695 ± 0.162 mm, p = 0.0038). In the study group there were significant correlations between i‐m thickness and age ( r = 0.65, p < 0.01), total serum cholesterol ( r = 0.32, p < 0.01), and serum fibrinogen ( r = 0.43, p < 0.01) but no other lipid or apolipoprotein variable. When i‐m thickness was corrected for age there were significant correlations with total cholesterol ( r = 0.43, p < 0.01) and LDL‐cholesterol ( r = 0.42, p < 0.01). Whereas total and LDL‐cholesterol and serum fibrinogen concentrations were related to the extent of atherosclerotic disease by ultrasound techniques, there was no relationship with high density lipoprotein (HDL) or subfraction cholesterol concentrations. HDL‐cholesterol may not be a useful marker for cardiovascular disease in Type 1 diabetes.