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Lipid Composition of Platelets in Patients with Non‐insulin‐dependent Diabetes Mellitus: Studies Before and After Treatment of Diabetes
Author(s) -
Tamasawa A.,
Onuma T.,
Tsutsui M.,
Boku A.,
Ochiai S.,
Takebe K.
Publication year - 1994
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1994.tb00270.x
Subject(s) - medicine , diabetes mellitus , platelet , insulin , endocrinology
The study was designed to investigate whether impaired composition of platelet lipids in untreated diabetic patients improved after diabetic treatment. Fourteen untreated patients with non‐insulin‐dependent diabetes mellitus (NIDDM) and 15 healthy control subjects were studied. In the diabetic patients, the ratio of free cholesterol to phospholipid (FC/PL) in platelets of 0.33 ± 0.02 (mean ± SEM) at pre‐treatment, which was statistically ( p < 0.05) higher than that of 0.26 ± 0.02 in control subjects, was significantly decreased to the value of 0.29 ± 0.02 ( p < 0.01) after insulin therapy. Platelet FC level of 9.77 ± 0.77 μg 10 −8 cells pre‐treatment was significantly ( p < 0.01) reduced to the value of 7.72 ± 0.38 μg 10 −8 cells post‐treatment. Platelet PL level showed no significant changes after the treatment. There was a significantly ( p < 0.01) positive correlation between the decrease in FC/PL of platelets and that in haemoglobin A 1c (HbA 1c ) after treatment for diabetes ( rs = −0.729). These results indicate that the impaired lipid composition in platelets can be improved after an adequate glycaemic control in patients with NIDDM.