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Preservation of Renal Haemodynamic Response to an Oral Protein Load in Non‐insulin‐dependent Diabetes Mellitus
Author(s) -
Vora J.P.,
Thomas D.,
Peters J.R.,
Coles G.A.,
Williams J.D.
Publication year - 1993
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1993.tb00153.x
Subject(s) - medicine , effective renal plasma flow , renal function , endocrinology , ingestion , diabetes mellitus , renal blood flow , basal (medicine) , filtration fraction , urology
Glomerular Filtration Rate (GFR) and Effective Renal Plasma Flow (ERPF) were determined, for 2h prior to and 3h following the ingestion of a 1.2 g kg −1 meat meal, in seven normotensive normoalbuminuric Type 2 diabetic patients exhibiting good glycaemic control (fasting plasma glucose (mean ± SD): 7.2 ± 2.0 mmol l −1 ; glycosylated haemoglobin: 8.1 ± 1.7%) and in nine normal subjects selected for similar basal GFR values. Baseline GFR and ERPF (corrected to 1.73 m 2 surface area) were 83 ± 10 and 410 ± 76 ml min −1 for the Type 2 diabetic patients and 86 ± 11 and 405 ± 113 ml min −1 for the normals. GFR increased by 38 ± 8 and 32 ± 15% in the diabetic patients and normals, to 108 ± 25 and 105 ± 26 ml min −1 ( p < 0.01 vs baseline). Peak ERPF was 501 ± 127 and 476 ± 119 ml min −1 for the two respective groups ( p < 0.01 vs baseline). Filtration fractions at peak GFR and EPRF values were unchanged from baseline for either groups. Fractional clearance of albumin for the Type 2 diabetic patients was unaltered by protein ingestion. Therefore, protein ingestion in Type 2 diabetes, as in normals, results in an acute elevation of GFR. Absolute and incremental changes in GFR were identical for the two groups. These data demonstrate a preserved capacity for renal vasodilatation in Type 2 diabetic patients despite their greater chronological age.