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Possible Link Between a Low Prevalence of Cardiovascular Disease and Mild Dyslipidaemia: a Study in Japanese Patients with Type 2 Diabetes
Author(s) -
Aizawa T.,
Kobayashi M.,
Sato Y.,
Tozuka M.,
Ishihara F.,
Okada N.,
Shigematsu S.,
Komatsu M.,
Hiramatsu K.,
Yamauchi K.,
Komiya I.,
Yamada T.,
Kanai M.,
Honda Z.,
Yoshizawa K.
Publication year - 1993
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1993.tb00094.x
Subject(s) - medicine , diabetes mellitus , triglyceride , cholesterol , type 2 diabetes , population , gastroenterology , endocrinology , type 2 diabetes mellitus , disease , risk factor , environmental health
In 98 Japanese patients with Type 2 diabetes mellitus, serum total cholesterol, triglyceride, high density lipoprotein cholesterol (HDL‐C), free fatty acid (FFA), and apolipoproteins (apo) A‐I, A‐II, B, C‐II, C‐III, and E were determined. The data were compared with those in 47 normolipidaemic normal controls. The total cholesterol value of the diabetic patients was also compared to that of a general population ( n = 2227). The diabetic patients were separated into those with cardiovascular disease ( n = 20) and without it ( n = 78) and a comparison of clinical characteristics and dyslipidaemia was also performed. The diabetic patients had slightly but significantly higher FFA, LDL‐C, apo B, C‐II, C‐III, E, and B/A‐I, and lower apo A‐I and A‐II compared to the normal controls. The total cholesterol level of the diabetic patients (5.17 ± 0.96 mmol −1 ) was not significantly higher than that of the general population (5.12 ± 0.91 mmol −1 ). By multivariate stepwise discriminant analyses, only total cholesterol significantly discriminated the patients with and without cardiovascular disease. In Japanese patients with Type 2 diabetes, a diabetic population with a very low prevalence of cardiovascular disease, high total cholesterol ís a risk factor for developing cardiovascular disease. Nevertheless, a markedly low prevalence of cardiovascular disease in Japanese with Type 2 diabetes compared to Caucasian counterparts may partly be due to the mildness of dyslipidaemia.