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An Evaluation of Bone Density and Turnover in Premenopausal Women with Type 1 Diabetes Mellitus
Author(s) -
Gallacher S.J.,
Fenner J.A.K.,
Fisher B.M.,
Quin J.D.,
Fraser W.D.,
Logue F.C.,
Cowan R.A.,
Boyle I.T.,
MacCuish A.C.
Publication year - 1993
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1993.tb00029.x
Subject(s) - medicine , endocrinology , bone remodeling , diabetes mellitus , osteoporosis , bone density , osteopenia , creatinine , glycated hemoglobin , type 2 diabetes mellitus , hydroxyproline , femoral neck , bone resorption , alkaline phosphatase , menopause , type 2 diabetes , bone mineral , biochemistry , chemistry , enzyme
Measurement of bone density and turnover was assessed in 20 premenopausal females with Type 1 diabetes mellitus and 27 age‐sex‐matched controls. Measurement was made of spinal (L2–4) and neck of femur bone density by dual‐energy X‐ray absorptiometry. L2–4 density was significantly higher in the diabetic patients compared with controls (1.224 ± 0.021 g cm −2 vs 1.161 ± 0.020 g cm −2 : p = 0.016). No significant difference was noted between the groups in neck of femur density. Measurement of bone formation was assessed by serum alkaline phosphatase and bone resorption by fasting urinary hydroxyproline/creatinine ratio. Alkaline phosphatase was significantly higher in the diabetic patients (185 ± 16 U l −1 vs 135 ± 10 U l −1 : p < 0.01) as was hydroxyproline/creatinine ratio (0.028 ± 0.003 vs 0.017 ± 0.002: p = 0.002). No significant correlation was found between L2–4 density and glycated haemoglobin, duration of diabetes or daily dose of insulin taken. These data suggest that osteopenia is not associated with Type 1 diabetes mellitus; however these patients do have evidence of increased bone turnover and may therefore be at risk of osteoporosis in later life, particularly after the menopause.