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Prevalence of Haemochromatosis Amongst Patients with Diabetes Mellitus
Author(s) -
Singh B.M.,
Grunewald R.A.,
Press M.,
Muller B.R.,
Wise P.H.
Publication year - 1992
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1992.tb01881.x
Subject(s) - medicine , transferrin saturation , hemochromatosis , diabetes mellitus , heterozygote advantage , population , gastroenterology , endocrinology , genotype , ferritin , genetics , serum ferritin , gene , environmental health , biology
Four hundred and six white Caucasian patients with diabetes mellitus (243 male, mean age 54 ± 16 (SD) years) were screened for haemochromatosis. Four patients had a fasting transferrin saturation > 62% and all were HLA A3 positive. Two were probable homozygotes for haemochromatosis and two heterozygotes. Homozygote haemochromatosis prevalence in this diabetic population was therefore 2/406 (0.0049) which is identical to that reported in the general population. These findings do not support a genetic relationship between the two conditions.