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Clinical and Laboratory Features of Type 1 Diabetic Children at the Time of Diagnosis
Author(s) -
LévyMarchal C.,
Papoz L.,
Beaufort C.,
Doutreix J.,
Froment V.,
Voirin J.,
Czernichow P.
Publication year - 1992
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1992.tb01777.x
Subject(s) - ketonuria , medicine , polyuria , incidence (geometry) , diabetes mellitus , pediatrics , population , family history , surgery , endocrinology , physics , environmental health , optics
The French incidence study has registered all new cases of Type 1 diabetic children under 20 years of age, from a population of 2.32 million, in an exhaustive and prospective manner. Three hundred and forty cases were identified between 1 January 1988 and 31 December 1989, yielding a mean annual incidence rate 7.3 per 10 5 . The lowest rate was observed in the youngest age group (0–4 yr: 4.1 per 10 5 ) and the highest around pubertal development (10–14 yr: 11.5 per 10 5 ). Details of the previous personal and family history, and the clinical and biological pictures of the disease at diagnosis were recorded. Almost 8 per cent of the children had a first‐degree relative with Type 1 diabetes. Polyuria, weight loss, fatigue and abdominal pain were the most frequently reported symptoms, which were of median duration 4.4 months. Mean weight loss before diagnosis was 9.4 ± 6.8 (±SD) % of body weight and was not significantly related to age. Ketonuria was detected in 83.8 per cent and acidosis (total CO 2 ≤ 18 mmol I −1 , if measured) in 48 per cent of the cases. Ketonuria and acidosis were significantly more frequent in the younger age group than in the rest of the group ( p < 0.001).