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‘Spontaneous’ Platelet Aggregation in Whole Blood in Diabetic Patients With and Without Microvascular Disease
Author(s) -
Hendra T. J.,
Yudkin J. S.
Publication year - 1992
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1992.tb01770.x
Subject(s) - medicine , platelet aggregation , disease , platelet , diabetes mellitus , cardiology , endocrinology
Consistent abnormalities of agonist‐induced platelet aggregation, in either whole blood or platelet rich plasma, have not been demonstrated in diabetic patients without microvascular disease. In the present study platelet aggregation in the absence of exogenous agonists (‘spontaneous’ aggregation) was compared between 22 non‐diabetic subjects and 23 Type 1 diabetic patients with ( n =12) and without ( n =11) microvascular disease. ‘Spontaneous’ aggregation was determined by measuring the percentage fall in single platelet number in aliquots of whole blood shaken for 60 min. Diabetic patients without microvascular disease had fewer single platelets remaining (greater aggregation) than non‐diabetic subjects at all time‐points (69.7 ± 6.6 vs 82.3 ± 7.3 % at 60 min p <0.001), but more platelets remaining than in diabetic patients with microvascular disease at all time‐points (69.7 ± 6.6 vs 61.0 ± 7.8 % at 60 min p <0.02). No significant correlations were observed between platelet aggregation and plasma glucose, blood cell counts, or glycated haemoglobin levels. The study suggests that platelet abnormalities antedate the appearance of microvascular disease in diabetic patients.