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Lipoprotein Lipids and Apolipoproteins (AI, AII, B, CII, CIII) in Type 1 and Type 2 Diabetes Mellitus in Young Kuwaiti Women
Author(s) -
AlMuhtaseb N.,
AlYusef A.R.,
Bajaj J.S.
Publication year - 1991
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1991.tb01692.x
Subject(s) - medicine , endocrinology , apolipoprotein b , fructosamine , type 2 diabetes , cholesterol , diabetes mellitus , body mass index , type 2 diabetes mellitus , lipoprotein , triglyceride
Plasma lipid and apolipoprotein levels of Type 1 and Type 2 young Kuwaiti diabetic women on insulin therapy were investigated to elucidate the relationship between coronary artery disease risk factors and lipid levels. Forty Type 1 and 52 Type 2 diabetic women and 45 and 62 corresponding control subjects (matched for age and body mass index) were investigated. In comparison with control subjects, both groups of diabetic patients showed marked increases in total‐cholesterol, LDL‐cholesterol, triglycerides, very low density triglycerides, apolipoprotein B, glucose, fructosamine, and glycosylated haemoglobin HbA 1c (all p < 0.001). However, apolipoprotein CIII was significantly elevated in Type 2 diabetic patients ( p < 0.001) but not in Type 1 patients. Concentrations of apolipoproteins CII and All in both diabetic groups were not significantly different from those in control subjects. Levels of HDL–, HDL 2 − and HDL 3 −cholesterol and plasma apolipoprotein AI were markedly decreased in both the diabetic groups compared with their control groups (all p < 0.001 except HDL 3 −cholesterol in Type 1 diabetic vs control, p < 0.05). In Type 2 diabetic patients, HbA 1c correlated positively with triglycerides ( r = 0.70, p < 0.001), cholesterol ( r = 0.60, p < 0.001), apolipoprotein B ( r = 0.77, p < 0.001), and apolipoprotein CIII ( r = 0.55, p < 0.001) and negatively with apolipoprotein AI ( r = −0.49, p < 0.001). In Type 1 diabetic patients HbA 1c correlated positively only with apolipoprotein CIII ( r = 0.50, p < 0.001).