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Blood Rheology and Cardiovascular Risk Factors in Type 1 Diabetes: Relationship with Microalbuminuria
Author(s) -
Jay R.H.,
Jones S.L.,
Hill C.E.,
Richmond W.,
Viberti G.C.,
Rampling M.W.,
Betteridge D.J.
Publication year - 1991
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1991.tb01674.x
Subject(s) - microalbuminuria , medicine , endocrinology , diabetes mellitus , fibrinogen , diabetic nephropathy , apolipoprotein b , lipoprotein(a) , excretion , cholesterol , lipoprotein , albumin , nephropathy , type 2 diabetes
Whole blood and plasma viscosity, erythrocyte aggregation and deformability, plasma fibrinogen, lipids, lipoproteins, apolipoproteins, and measures of blood glucose control were compared between 21 Type 1 diabetic patients with microalbuminuria (overnight albumin excretion rate 30–200 μg min −1 ) and 21 patients with albumin excretion below this range matched for age, sex, and duration of diabetes. Patients with microalbuminuria had significantly higher glycosylated haemoglobin (9.4±1.6 (±SD) vs 7.9±1.8% (normal range 5.0 to 7.6%)), total‐cholesterol (5.6±1.1 vs 4.6±1.3 mmol I −1 ), apolipoprotein B (0.82±0.21 vs 0.66±0.14 g I −1 ), and apolipoprotein B:A1 ratio (0.58±0.18 vs 0.50±0.15) than those without microalbuminuria (all p <0.05). HDL‐cholesterol was also raised (1.71±0.46 vs 1.43±0.37 mmol I −1 , p <0.05). Lipoprotein(a) concentration was possibly higher in the microalbuminuric group (median (95% CI) 105 (82–140) vs 72 (52–114) mg I −1 , p =0.06). No differences were seen in any of the rheological measurements. These results confirm the presence of potentially atherogenic lipoprotein changes in Type 1 diabetic patients with microalbuminuria, but suggest that altered blood rheology does not predate the development of nephropathy.