Premium
Metabolic Control May Influence the Increased Superoxide Generation in Diabetic Serum
Author(s) -
Ceriello A.,
Giugliano D.,
Quatraro A.,
Russo P. Dello,
Lefèbvre P.J.
Publication year - 1991
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1991.tb01647.x
Subject(s) - medicine , endocrinology , superoxide , metabolic control analysis , diabetes mellitus , ex vivo , in vivo , enzyme , biochemistry , biology , microbiology and biotechnology
Superoxide anion (O 2 ‐ ) generation in serum from 10 Type 1 diabetic patients and 10 normal subjects was measured ex vivo. The amount of O 2 ‐ production was significantly increased in diabetic serum 0.41 ± 0.04 (±SD) vs 0.14 ± 0.04 μmol l −1 min −1 , p < 0.001) and correlated with fasting plasma glucose and glycosylated protein levels in both diabetic ( r = 0.72, p < 0.01, and r = 0.62, p < 0.05) and normal ( r = 0.75, p < 0.01 and r = 0.64, p < 0.05) subjects. Improved metabolic control in the diabetic patients was associated with a reduction of serum O 2 ‐ production (0.28 ± 0.06 μmol l −1 min −1 , p < 0.01), but the correlation between O 2 ‐ levels and fasting plasma glucose and glycosylated protein concentrations was retained ( r = 0.86 and r = 0.72, respectively, both p < 0.01).