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Reactive Hypoglycaemia in Association with Disordered Islet Function and Abnormal Hepatic Glucose‐6‐Phosphatase Activity: Response to Diazoxide
Author(s) -
Pears J.,
Jung R. T.,
Browning M. C. K.,
Taylor R.,
Burchell A.
Publication year - 1991
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1991.tb01584.x
Subject(s) - medicine , endocrinology , diazoxide , somatostatin , glucagon , insulin , islet , hypoglycemia , octreotide
Severe reactive hypoglycaemia was confirmed in a non‐diabetic male patient by a counter‐regulatory hormone (GH, cortisol and catecholamine) response to profound hypoglycaemia induced by an intravenous glucose load. There was also evidence of disordered pancreatic islet cell paracrine regulation with hyperinsulinaemia and absent glucagon response to hypoglycaemia. A defect in the patient's hepatic glucose‐6‐phosphatase enzyme system was documented. Because of severe symptoms, dietary control was insufficient, but the patient responded clinically and biochemically to 18 months of oral diazoxide therapy. He also showed good biochemical response to a single dose (100 μg IM) of the somatostatin analogue octreotide.