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Do Rheological Variables Play a Role in Diabetic Peripheral Neuropathy?
Author(s) -
MacRury S. M.,
Lockhart J. C.,
Small M.,
Weir A. I.,
MacCuish A. C.,
Lowe G. D. O.
Publication year - 1991
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1991.tb01578.x
Subject(s) - medicine , peripheral neuropathy , diabetic neuropathy , diabetes mellitus , etiology , blood viscosity , peripheral , endocrinology , shear rate , gastroenterology , rheology , composite material , materials science
Whole blood viscosity and its determinants were measured in diabetic patients with and without peripheral neuropathy to assess whether these variables could have a role in the microvascular aetiology of diabetic peripheral neuropathy. Although corrected whole blood viscosity at high and low shear rates (5.29 ± 0.51 and 21.10 ± 3.03 mPa s), plasma viscosity (1.41 ± 0.13 mPa s), and red cell filtration ratio (0.49 ± 0.04) in diabetic patients were significantly different from non‐diabetic control subjects (high shear rate 4.83 ± 0.54, low shear rate 17.36 ± 2.78, plasma 1.29 ± 0.09 mPa s, all p < 0.001, and red cell filtration ratio 0.55 ± 0.03, p < 0.001) there were no significant differences between diabetic patients with neuropathy and those without. Blood rheology is altered to a similar extent in diabetic patients with and without neuropathy.