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Regression of Left Ventricular Hypertrophy with 1 Year of Antihypertensive Treatment in Type 1 Diabetic Patients with Early Nephropathy
Author(s) -
Sampson M. J.,
Chambers J. B.,
Sprigings D. C.,
Drury P. L.
Publication year - 1991
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1991.tb01554.x
Subject(s) - medicine , blood pressure , left ventricular hypertrophy , microalbuminuria , cardiology , enalapril , muscle hypertrophy , diastole , proteinuria , diabetic nephropathy , endocrinology , angiotensin converting enzyme , kidney
M‐mode echocardiograms were recorded in 22 Type 1 diabetic patients with microalbuminuria ( n = 10) or early persistent proteinuria ( n = 12). Eight (36%) had both an increased left ventricular mass (males > 131 g m −2 ; females > 100 g m −2 ) and a systolic blood pressure above the 75th centile of the normal blood pressure distribution. These eight patients were treated with antihypertensive drugs, predominantly enalapril, for 1 year. Echocardiograms were repeated after 3 and 12 months. Systolic blood pressure at recruitment was 155 ± 14 (± SD) mmHg, and was significantly lower after 3 months (146 ± 12 mmHg; p < 0.05) and 12 months (139 ± 8 mmHg; p < 0.005). Diastolic blood pressure did not change significantly. Both intraventricular septal width and left ventricular posterior wall thickness fell progressively and were significantly lower after 12 months treatment (15.0 ± 2.7 vs 13.0 ± 2.6 mm, and 10.3 ± 1.9 vs 8.8 ± 1.3 mm; both p < 0.05). Left ventricular mass index was 148 ± 29 g m −2 at recruitment, but lower after 3 months (131 ± 25 g m −2 ; p < 0.05) and 12 months (132 ± 26 g m −2 ; p < 0.005) antihypertensive therapy.