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Deterioration in Blood Glucose Control in Females with Diabetes Changed to a Basal‐bolus Regimen Using a Pen‐injector
Author(s) -
Hardy K.J.,
Jones K.E.,
Gill G.V.
Publication year - 1991
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1991.tb01518.x
Subject(s) - medicine , diabetes mellitus , bolus (digestion) , regimen , insulin , basal (medicine) , surgery , endocrinology
Although the basal‐bolus regimen of insulin delivery is more physiological than conventional twice daily insulin it does not usually improve blood glucose control. Having recently withdrawn 3 patients from pen‐injector therapy for deteriorated blood glucose control we examined the records of all our diabetic patients on a pen‐injector for at least 1 year. Of the 51 patients identified, 3 had died, 2 moved away, and 4 patients (3 females) had pen‐injector therapy withdrawn for poor control; 3 patients had inadequate records. The remaining 21 males and 18 females were well matched for age, duration of diabetes, and duration of pen‐injector treatment. Blood glucose control deteriorated significantly during pen‐injector therapy in female patients (9.6 ± 1.2 to 10.7 ± 1.4%, p = 0.02), but not in the males (9.3 ± 1.3 vs 9.4 ± 1.4%, NS). Weight and insulin dose did not change significantly in any patient. Blood glucose control may deteriorate in young women with diabetes changed to insulin therapy with a pen‐injector