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A Comparative Study of Microvascular Complications in Patients with Secondary and Type 1 Diabetes
Author(s) -
Larsen S.,
Hilsted J.,
Philipsen E.K.,
LundAndersen H.,
Parving HH.,
Worning H.
Publication year - 1990
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1990.tb01498.x
Subject(s) - medicine , microalbuminuria , diabetes mellitus , albuminuria , retinopathy , diabetic retinopathy , type 1 diabetes , type 2 diabetes , nephropathy , insulin , gastroenterology , surgery , endocrinology
The prevalences of retinopathy, albuminuria, and neuropathy were assessed in 25 patients with insulin‐requiring diabetes secondary to chronic pancreatitis and in 25 patients with Type 1 (insulin‐dependent) diabetes, matched for age at diabetes onset (secondary, 39 ± 11 (± SD) years vs Type 1, 38 ± 11 years) and duration of diabetes (10 ± 6 vs 10 ± 7 years). The prevalence of retinopathy was significantly higher in Type 1 diabetic patients (52 %) than those with secondary diabetes (20 %) ( p < 0.02). Median urinary excretion of albumin was 9 (range 1–206) mg 24‐h −1 in patients with Type 1 diabetes and 7 (1–90) mg 24‐h −1 in patients with secondary diabetes (NS). One secondary diabetic patient and five Type 1 diabetic patients had microalbuminuria (NS). Vibration perception threshold (measured at the big toe) was identical in the two groups of patients, and no patient had a threshold indicating somatic neuropathy (biothesiometry > 20 V). Retinopathy is more frequent in patients with Type 1 diabetes than in patients with insulin‐requiring diabetes secondary to chronic pancreatitis. Retinopathy is so frequent in the latter group, however, that regular ophthalmoscopic examination is still required.