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Pathogenesis of Diabetic Neuropathy: the Role of the n‐6 Essential Fatty Acids and their Eicosanoid Derivatives
Author(s) -
Jamal G.A.
Publication year - 1990
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1990.tb01451.x
Subject(s) - medicine , eicosanoid , pathogenesis , diabetic neuropathy , hypoxia (environmental) , diabetes mellitus , myelin , receptor , endocrinology , enzyme , biochemistry , arachidonic acid , biology , central nervous system , oxygen , chemistry , organic chemistry
A substantial disturbance of the metabolism of the n‐6 essential fatty acids exists in both human and experimental diabetes mellitus. Disturbances of the essential fatty acids and of the 1‐ and 2‐series prostaglandins derived from them create a variety of microvascular, haemorheological, and other abnormalities leading to reduced blood flow and neural hypoxia which will in turn produce a cycle of hypoxia. Disturbance of the n‐6 pathway may also result in functional and structural abnormalities of the axon, the myelin, and membrane‐bound proteins such as enzymes and receptors. Metabolic disturbances identified previously may have a synergistic effect in enhancing these pathogenetic changes.