Premium
The Role of Hyperglycaemia‐induced Alterations of Antithrombin III and Factor X Activation in the Thrombin Hyperactivity of Diabetes Mellitus
Author(s) -
Ceriello A.,
Quatraro A.,
Marchi E.,
Barbanti M.,
Russo P. Dello,
Lefebvre P.,
Giugliano D.
Publication year - 1990
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1990.tb01402.x
Subject(s) - antithrombin , medicine , endocrinology , thrombin , diabetes mellitus , factor x , heparin , platelet
Factor X concentration and factor X activation, antithrombin III anti‐Xa activity and plasma concentration, and fibrinopeptide A were measured in 20 diabetic patients and 20 normal subjects. Although factor X activation (81.3 ± 2.2 vs 97.3 ± 2.1 %, p < 0.01; mean ± SE) and antithrombin III activity (76.5 ± 2.2 vs 96.3 ± 1.8 %, p < 0.01) were reduced in the diabetic patients, fibrinopeptide A concentration was increased (3.7 ± 0.4 vs 1.7 ± 0.2 ng ml −1 , p < 0.01). The ratio of factor X activation to antithrombin III anti‐factor Xa activity was increased in the diabetic patients (1.10 ± 0.01 vs 1.01 ± 0.02, p < 0.01). Induced hyperglycaemia was able to mimic all these abnormalities, without changing factor X or antithrombin III concentration. The results suggest that in vivo hyperglycaemia produces a decrease of factor X activation, but at the same time increases fibrinopeptide A formation due to a greater decrease of antithrombin III anti‐Xa activity.