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Decreased Insulin Sensitivity in Offspring Whose Parents Both Have Type 2 Diabetes
Author(s) -
Ramachandran A.,
Snehalatha C.,
Mohan V.,
Bhattacharyya P. K.,
Viswanathan M.
Publication year - 1990
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1990.tb01400.x
Subject(s) - offspring , medicine , endocrinology , insulin , hyperinsulinism , insulin tolerance test , diabetes mellitus , impaired glucose tolerance , glucose tolerance test , type 2 diabetes , insulin resistance , insulin sensitivity , pregnancy , biology , genetics
Offspring of two Type 2 diabetic parents have a high prevalence of diabetes and impaired glucose tolerance. Studies in normoglycaemic offspring have shown abnormal insulin responses. Twenty‐four non‐obese offspring having normal oral glucose tolerance were investigated by the insulin tolerance test for abnormalities of insulin sensitivity. Plasma insulin responses were measured during an oral glucose tolerance test. Although the plasma glucose responses during the OGTT were similar to the control values, the corresponding insulin responses were higher. The mean area under the insulin curve was 121 ± 29 (± SD) mU I −1 h in the control subjects and 203 ± 73 mU I −1 h in the offspring ( p < 0.001). The mean K ITT value in the offspring was 4.3 ± 1.9 min −1 × 100 which was significantly lower ( p < 0.01) than the value of 6.2 ± 2.0 min −1 × 100 in the control subjects. The results suggest that some offspring of two Type 2 diabetic parents have low insulin sensitivity and the presence of hyperinsulinism may be a compensatory phenomenon.