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Antibodies to Proinsulin and Insulin as Predictive Markers of Type 1 Diabetes
Author(s) -
Kuglin B.,
Rjasanowski I.,
Bertrams J.,
Gries F.A.,
Kolb H.,
Michaelis D.
Publication year - 1990
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1990.tb01395.x
Subject(s) - medicine , proinsulin , antibody , type 2 diabetes , insulin , endocrinology , diabetes mellitus , type 1 diabetes , immunology
The aim of the present study was to test whether proinsulin autoantibodies (IgG‐PAA), insulin autoantibodies (IgG‐IAA), and islet cell antibodies (ICA) may be used to identify subjects at risk for Type 1 diabetes. Pre‐diabetic sera from 18 individuals who later developed diabetes were tested. Results were compared with 18 age‐, sex‐, and HLA‐DR‐matched non‐diabetic control subjects from families with Type 1 diabetes. At a mean of 2.4 yr before the onset of diabetes, ICA were found in 13 patients (vs 0 control subjects, p < 0.001), ELISA‐determined IgG‐IAA in 8 patients (vs 1 control subject, p < 0.05) and ELISA‐determined IgG‐PAA in 4 patients (vs 2 control subjects, NS). ELISA‐determined IgG‐PAA do not appear to be useful predictors of the future development of Type 1 diabetes.