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Acute Changes in Plasma Non‐esterified Fatty Acid Concentration do not Change Hepatic Glucose Production in People with Type 2 Diabetes
Author(s) -
Johnston P.,
Hollenbeck C.,
Sheu W.,
Chen Y.D. I.,
Reaven G. M.
Publication year - 1990
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1990.tb01321.x
Subject(s) - nefa , medicine , endocrinology , fatty acid , diabetes mellitus , plasma glucose , mole , insulin , chemistry , biochemistry
The effect of changes in plasma non‐esterified fatty acid concentration (NEFA) on plasma glucose concentration, hepatic glucose production ( R a ), and glucose disposal ( R d ) rates was determined in 14 patients with Type 2 diabetes. Seven patients had relatively mild fasting hyperglycaemia (< 10.0 mmol l −1 ), whereas the remaining seven had relatively severe fasting hyperglycaemia (> 14.0 mmol l −1 ). Each patient was infused from 2000 to 0800 h with 3‐ 3 H‐glucose on two occasions, with or without neutral fat emulsion and heparin (mild hyperglycaemia group), or with or without nicotinic acid (severe hyperglycaemia group). Plasma NEFA concentration increased from 0.33 ± 0.06 (± SE) to 4.78 ± 0.42 mmol l −1 in response to the lipid and heparin infusion, but plasma glucose concentration (7.8 ± 0.7 vs 7.4 ± 0.8 mmol l −1 ), R a (0.44 ± 0.02 vs 0.46 ± 0.02 mmol m −2 min −1 ), and R d (0.42 ± 0.02 vs 0.46 ± 0.02 mmol m −2 min −1 ) were unchanged. Nicotinic acid decreased plasma NEFA concentration from 0.54 ± 0.15 to 0.23 ± 0.08 mmol l −1 , but plasma glucose (15.0 ± 1.0 vs 15.5 ± 1.4 mmol l −1 ), R a (0.74 ± 0.07 vs 0.68 ± 0.07 mmol m −2 min −1 ), and R d (0.73 ± 0.07 vs 0.68 ± 0.07 mmol m −2 min −1 ) were unchanged. The results indicate that acute changes in plasma NEFA concentration did not lead to any change in overnight glucose production or disposal rates.