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An Acceptable Exercise Test to Study Microalbuminuria in Type 1 Diabetes
Author(s) -
Watts G.F.,
Morris R.W.,
Mandalia S.,
Williams I.,
Polak A.,
Shaw K.M.
Publication year - 1989
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1989.tb01280.x
Subject(s) - microalbuminuria , medicine , excretion , endocrinology , blood pressure , diabetes mellitus , type 2 diabetes , albuminuria , heart rate , renal function , albumin
A modified test for studying the response of urinary albumin excretion ( U A V ) to exercise in diabetic patients is described. It is designed to produce a standardized increase in pulse rate (by 90–110 %) rather than a standardized workload. Thirty‐three normotensive Type 1 diabetic patients with normal pre‐exercise U A V (<10 μg min −1 ) on the day of the test were compared with 25 non‐diabetic subjects matched for age and sex. The patients developed a significantly greater increase in the median U A V ( p < 0.05) and systolic blood pressure ( p < 0.01) during exercise, despite the use of lower workloads ( p < 0.05). During exercise, the albumin excretion in the patients was not related to their heart rate, blood pressure, workload or fall in blood glucose; nor was it related to duration of diabetes, glycosylated haemoglobin or insulin dose. An exercise U A V > 15 μg min −1 was found in 10 of the 33 patients; it was significantly correlated ( p < 0.01) with the frequency of previous overnight microalbuminuria (> 10 μg min −1 ), and was associated with a greater progression of microalbuminuria ( p < 0.05) over a mean period of 24 months. Retinol‐binding protein excretion rate was also measured as an indicator of proximal tubular function and did not increase in either group.