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Activity of the Unstimulated Renin—Angiotensin—Aldosterone System in Type 1 Diabetic Patients with and without Proteinuria
Author(s) -
O'Donnell M.J.,
Lawson N.,
Barnett A.H.
Publication year - 1989
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1989.tb01197.x
Subject(s) - medicine , endocrinology , albuminuria , plasma renin activity , aldosterone , renin–angiotensin system , proteinuria , blood pressure , diabetes mellitus , excretion , renal function , kidney
There have been conflicting reports of the activity of the renin‐angiotensin‐aldosterone system in diabetes. We studied the activity of the unstimulated renin‐angiotensin‐aldosterone system in 73 consecutive Type 1 diabetic patients with varying degrees of albuminuria. Patients with elevated albumin excretion rates had elevated median plasma renin activity (macroalbuminuric 2.2, range 0.5–8.2, p < 0.05; microalbuminuric 2.3, 0.7–7.1, p < 0.001; vs normoalbuminuric 1.0, 0.2–4.5 nmol l −1 h −1 ) and higher systolic blood pressure (macroalbuminuric 141 ± 27 vs normoalbuminuric 116 ± 13 mmHg, mean ± SD, p < 0.01) compared with those with normal albumin excretion rates. Aldosterone secretion and function were normal in all patients studied.