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Co‐occurrence of Hypercalciuria and Hypouricaemia in Type 2 Diabetic Patients
Author(s) -
Ishihara M.,
Shinoda T.,
Yamada T.
Publication year - 1989
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1989.tb01194.x
Subject(s) - medicine , uric acid , endocrinology , hypercalciuria , excretion , creatinine , calcium , urinary calcium , urinary system , renal function
The relationship between the urinary excretion of calcium (Ca 2+ ) and uric acid was investigated in 151 Type 2 diabetic patients and 48 normal subjects. In the diabetic patients, uric acid clearance/creatinine clearance (Cl urate /Cl cr ) was higher and the serum level of uric acid was lower than in the normal subjects (Cl urate /Cl cr : 10.9 ± 5.8 vs 8.1 ± 2.6%, p < 0.001; serum uric acid: 304 ± 86 vs 357 ± 89 μmol l −1 , p < 0.001). Calcium clearance/Cl cr (Cl ca /Cl cr ) also increased in the diabetic patients, as did urinary excretion rate, but the serum Ca 2+ level was not different to normal control subjects (Cl ca /Cl cr : 2.29 ± 1.59 vs 1.56 ± 0.98%, p < 0.001; Ca 2+ excretion rate: 2.24 ± 1.67 vs 1.63 ± 1.11 mmol day −1 , p < 0.01; serum Ca 2+ level: 2.34 ± 0.11 vs 2.33 ± 0.08 mmol l −1 ). In the diabetic patients, Cl cr positively and the serum uric acid negatively correlated with the urinary excretion of Ca 2+ ( p < 0.001 for both correlations in the multivariate regression analysis). These data suggest that the diabetic patients have increased fractional excretion of both Ca 2+ and uric acid.