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Serum Lipids and Lipoproteins in Insulin‐dependent Diabetic Patients with Persistent Microalbuminuria
Author(s) -
Watts G. F.,
Naumova R.,
Slavin B. M.,
Morris R. W.,
Houlston R.,
Kubal C.,
Shaw K. M.
Publication year - 1989
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1989.tb01134.x
Subject(s) - microalbuminuria , medicine , endocrinology , excretion , apolipoprotein b , cholesterol , diabetes mellitus , insulin , albumin , lipoprotein , high density lipoprotein , albuminuria
Serum lipid and lipoprotein concentrations were measured in 18 insulin‐dependent diabetic patients with persistent microalbuminuria and an equal number with persistently normal albumin excretion. The groups were matched for sex, age, duration of diabetes, body mass index, insulin dose, and glycosylated haemoglobin. Diabetic patients with persistent microalbuminuria were found to have a significantly lower high density lipoprotein (HDL) cholesterol concentration (difference 0.29,95 % Cl 0.12 to 0.46, mmol l −1 , p < 0.01) and a higher low density lipoprotein (LDL) cholesterol:HDL cholesterol ratio (difference 0.97, 95% Cl 0.29 to 1.65, p < 0.01) than patients with normal albumin excretion. No significant differences were found in total cholesterol, triglycerides, LDL cholesterol, apolipoprotein (apo) A‐***I and apo B concentrations. Compared to an age and sex‐matched group of non‐diabetic subjects with normal albumin excretion, diabetic patients with persistent microalbuminuria had significantly higher concentrations of total cholesterol ( p < 0.05), LDL cholesterol ( p < 0.05) and apo B ( p < 0.01), but a lower concentration of HDL cholesterol ( p < 0.05). No significant differences were found in serum lipids and lipoproteins between diabetic patients with normal albumin excretion and non‐diabetic subjects.