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Glycosylated Haemoglobin in Clarification of the Origin of Hyperglycaemia in Acute Cerebrovascular Accident
Author(s) -
Topić E.,
Pavliček I.,
Brinar V.,
Koršić M.
Publication year - 1989
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1989.tb01131.x
Subject(s) - medicine , accident (philosophy) , intensive care medicine , epistemology , philosophy
In 148 patients admitted to hospital with acute cerebrovascular accidents (CVA), the levels of glycosylated haemoglobin (HbA 1c ) and blood glucose were measured to evaluate the effect of the duration and severity of hyperglycaemia on stroke outcome. Eighty‐eight (59%) patients had clearly normal blood glucose and HbA 1c concentrations (blood glucose < 5.5 mmol l −1 , HbA 1c < 8.6%). The remaining 60 patients were defined as hyperglycaemic. Nineteen (13%) had known diabetes, whereas in 23 (16%) hyperglycaemia was probably due to unrecognized diabetes. In 18 (12%) patients transient hyperglycaemia was observed. Recovery after CVA was best among normoglycaemic patients (good 45%, moderate 29%, poor 14%, fatal 12%) and poorest among diabetic patients (moderate 21%, poor 37%, fatal 42%). Fatal outcome in patients from the normoglycaemic group differed significantly from patients belonging to known diabetic and unrecognized diabetic groups ( p < 0.05), but was not different from that in patients with transient hyperglycaemia, who did however differ from both diagnosed and unrecognized diabetic patients ( p < 0.05). No significant differences were found between CVA outcome in the known diabetic and unrecognized diabetic groups.