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A Randomized Trial of the Efficacy and Acceptability of a Pen Injector
Author(s) -
Murray D. P.,
Keenan P.,
Gayer E.,
Salmon P.,
Tomkin G. H.,
Drury M. I.,
O'Sullivan D. J.
Publication year - 1988
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1988.tb01102.x
Subject(s) - medicine , regimen , randomized controlled trial , syringe , insulin pen , patient satisfaction , surgery , physical therapy , insulin , psychiatry
A controlled trial of pen injection of insulin was performed in 78 patients, with assessment of metabolic control and lifestyle. After a 6‐week run‐in period, during which control was optimized, the patients were randomized, either to stay on a twice daily insulin regimen ( n = 37), or to change to a three times daily pen regimen with human ultralente at night ( n = 41). Over the 20 weeks, there was no significant change in mean glycosylated haemoglobin (syringe, mean ± SD, 11.1±2.5% to 10.9±2.0%; pen, 11.3±2.6% to 11.2±2.0%), in blood glucose profiles or in frequency of hypoglycaemic attacks in either group. A self‐completed questionnaire demonstrated high patient satisfaction with the pen injector (NovoPen), 78% for effect on lifestyle and 81% for increased flexibility. Ninety‐five percent preferred the pen injector regimen to conventional treatment and stayed on it.