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Diabetes in Hypertensive Women: an Effect of Antihypertensive Drugs or the Hypertensive State Per Se ?
Author(s) -
Bengtsson C.,
Blohmé G.,
Lapidus L.,
Lundgren H.
Publication year - 1988
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1988.tb00981.x
Subject(s) - medicine , diabetes mellitus , blood pressure , antihypertensive drug , diastole , cardiology , endocrinology
A total of 226 women participating in a longitudinal study who were found to be hypertensive (initial values ≥160 mmHg for the systolic blood pressure and/or >95 mmHg for the diastolic blood pressure) were followed up with respect to the risk of developing diabetes during a 12‐year study period. For each year of follow‐up, information on whether each participant was taking antihypertensive drugs or not was collected. As a result there were 1339 ‘treatment years’ and 1449 ‘non‐treatment years’ of follow‐up. All 16 women who developed diabetes during the follow‐up period were taking antihypertensive drugs at the time of onset of their diabetes. A similar observation was made when 145 women within the upper age‐specific decentiles of systolic blood pressure were followed up in the same way. These results suggest that in hypertensive subjects antihypertensive drugs rather than the hypertensive state per se predispose to diabetes mellitus.