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A Rise in the Plasma Activities of Hepatic Enzymes is not a Common Consequence of Hypoglycaemia
Author(s) -
Jones R. G.,
Grant P. J.,
Brown D.,
Stickland M.,
Wiles P. G.
Publication year - 1988
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1988.tb00979.x
Subject(s) - medicine , endocrinology , vasopressin , enzyme , hormone , liver enzyme , hypoglycemia , insulin , plasma glucose , biochemistry , biology
Eight otherwise healthy insulin‐dependent diabetic patients were subjected to controlled, symptomatic hypoglycaemia for 20 min (median glucose concentration 1.7 mmol/l, range 1.0–2.6 mmol/l). Concentrations of plasma adrenaline and plasma vasopressin were significantly increased, indicating normal counter‐regulatory responses for these hormones. Plasma activities of the hepatic enzymes AST, ALT, LDH, GGT, and CK did not increase during or following the period of hypoglycaemia. Thus, abnormal plasma enzyme activities noted after clinical hypoglycaemia should be fully investigated, and not disregarded as due to the hypoglycaemic episode.