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Hypertriglyceridaemia and Diabetes Mellitus: Cause or Effect?
Author(s) -
Thomas D. J. B.,
Stocks J.,
Galton D. J.,
Besser C. M.
Publication year - 1988
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1988.tb00948.x
Subject(s) - medicine , diabetes mellitus , triglyceride , xanthoma , pill , endocrinology , oral contraceptive pill , cholesterol , apolipoprotein b , gastroenterology , population , family planning , environmental health , pharmacology , research methodology
Two patients with hypertriglyceridaemia which was diagnosed several years before the onset of diabetes are described. In the first case a 54‐year‐old man presented with hypertriglyceridaemia and normal glucose tolerance. After 4 years he developed severe hypertriglyceridaemia (22 mmol/l) which was first ascribed to poor compliance but soon afterwards diabetes was diagnosed and good blood glucose control minimized the hypertriglyceridaemia. The second patient, a female, aged 27 years, with the polycystic ovarian syndrome, presented with eruptive xanthoma after several years of mild hyperlipidaemia. There was severe hyperlipidaemia (triglyceride 140 mmol/l, cholesterol 42 mmol/l) which required urgent plasmaphoresis. Diabetes was diagnosed and treated with insulin at this time but the patient was taking the oral contraceptive pill and also had a deficiency of apolipoprotein Cll.