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The Effect of Metformin on Glycaemic Control, Intermediary Metabolism and Blood Pressure in Non‐insulin‐dependent Diabetes Mellitus
Author(s) -
Campbell I. W.,
Duncan C.,
Patton N. W.,
Broadhead T.,
Tucker G. T.,
Woods H. F.
Publication year - 1987
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1987.tb00895.x
Subject(s) - medicine , endocrinology , metformin , blood pressure , insulin , diabetes mellitus , hyperinsulinism , carbohydrate metabolism , insulin resistance
Fourteen non‐insulin‐dependent diabetics (9 female, 5 male), aged 46 to 64 years, uncontrolled by diet (fasting plasma glucose ≥8 mmol/l), were treated with metformin, 1–3 g daily, and followed prospectively at 1 week, then at 2‐weekly intervals for 6 months. The fasting plasma glucose fell significantly ( p <0.01) after 1 week of therapy and HbA 1 showed a significant reduction, 13.4 ± 2.5% (mean ±SD) to 10.7 ± 1.8% (normal range 5.1–9.3%) at 8 weeks ( p <0.001). There was no significant change in body weight, plasma insulin, serum cholesterol or triglycerides, blood lactate, pyruvate, glycerol, alanine, 3‐hydroxybutyrate or acetoacetate concentrations. Systolic, diastolic, and mean arterial blood pressures, along with resting heart rate remained unchanged. This study shows that metformin effectively lowers plasma glucose without hyperinsulinism or significant rise in fasting blood lactate and other gluconeogenic precursors.