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Abnormal Cerebrovascular Carbon Dioxide Reactivity in People with Diabetes
Author(s) -
Griffith D. N. W.,
Saimbi S.,
Lewis C.,
Tolfree S.,
Betteridge D. J.
Publication year - 1987
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1987.tb00865.x
Subject(s) - normocapnia , medicine , hypercapnia , diabetes mellitus , inhalation , cerebral blood flow , anesthesia , cardiology , endocrinology , acidosis
Cerebral blood flow was measured both under conditions of normocapnia and hypercapnia in 22 diabetic patients and 20 normal control subjects, using either the intravenous 133 Xe method or the closely comparable 133 Xe inhalation method. While 19 out of 20 control subjects responded appropriately to hypercapnia with an increase in flow, eight of the diabetic patients failed to respond normally, this difference being significant ( p = 0.03). Those manifesting an abnormal response included young, insulin‐dependent patients with a short duration of diabetes and no clinical evidence of complications.