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The Effects of One Month High Fructose Intake on Plasma Glucose and Lipid Levels in Non‐insulin‐dependent Diabetes
Author(s) -
McAteer E. J.,
O'Reilly G.,
Hadden D. R.
Publication year - 1987
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1987.tb00831.x
Subject(s) - fructose , medicine , endocrinology , triglyceride , diabetes mellitus , carbohydrate , insulin , cholesterol , plasma glucose , fructolysis , chemistry , metabolism , biochemistry
The effects of a high fructose diet on the control of blood glucose and serum lipids were studied in 10 non‐insulin‐dependent diabetic patients (mean age 64.4 years, mean duration of diabetes 5.6 years). Comparison was made following 28 days on the usual diabetic diet and 28 days during which 25% of the usual carbohydrate was substituted with fructose. There was no change in mean (± SEM) fasting plasma glucose (on usual diet 9.2 ± 0.5 mmol/l, on fructose diet, 9.1 ± 0.4 mmol/l), but there was a fall in mean plasma glucose levels at 30, 60, and 120 min in a 75 g OGTT following the fructose diet. There was no significant change in fasting lipids: on usual diet mean serum cholesterol 5.8 ± 0.2 mmol/l, on fructose diet 5.6 ± 0.2 mmol/l; serum triglyceride, on usual diet 1.3 ± 0.1 mmol/l, on fructose diet 1.3 ± 0.1 mmol/l; HDL cholesterol on usual diet 1.4 ± 0.1 mmol/l, on fructose diet 1.4 ± 0.1 mmol/l. Mean body weight did not vary significantly between the two diets. Incorporation of fructose into the diabetic diet may lower post‐prandial glucose levels without disturbing serum lipids.