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Influence of Metabolic Control of Insulin‐dependent Diabetes on Plasma Nucleotide Levels (cAMP, cGMP) During Bicycle Exercise
Author(s) -
Kuzmits R.,
Schernthaner G.
Publication year - 1986
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1986.tb00787.x
Subject(s) - medicine , endocrinology , diabetes mellitus , insulin , metabolic control analysis , physical exercise , plasma glucose , nucleotide , biology , biochemistry , gene
Plasma concentrations of cyclic nucleotides (cAMP, cGMP) were measured before and during bicycle exercise in 8 well‐controlled (mean pre‐exercise blood glucose 5.3 mmol/l; HbA 1 8.6%) and 8 moderately controlled (mean pre‐exercise blood glucose 12.2 mmol/l; HbA, 1 10.8%) patients aged 18–32 years with insulin‐dependent diabetes mellitus (IDDM) and in a group of non‐diabetic control subjects matched for age and sex. Pre‐exercise plasma cAMP concentrations and the rise with exercise were similar in all study groups. Significantly lower resting cGMP levels were found in well‐controlled IDDM patients (3.5 ± 0.3 pmol/ml, mean ± SEM) compared to controls (5.6 ± 1.1 pmol/ml; p <0.05) and moderately controlled IDDM patients (5.6 ± 1.0 pmol/ml; p <0.05). By contrast, plasma cGMP levels increased during exercise in the diabetics but not in the controls. These findings indicate a significant difference in responses of plasma cGMP to exercise between IDDM patients and controls.