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Long‐Term Effects of Intestinal Alpha‐Glucosidase Inhibition on Postprandial Glucose, Pancreatic and Gut Hormone Responses and Fasting Serum Lipids in Diabetics on Sulphonylureas
Author(s) -
Uttenthal L. O.,
Ukponmwan O. O.,
Wood S. M.,
Ghiglione M.,
Ghatei M. A.,
Trayner I. M.,
Bloom S. R.
Publication year - 1986
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1986.tb00728.x
Subject(s) - postprandial , acarbose , medicine , endocrinology , gastric inhibitory polypeptide , insulin , motilin , glycosuria , gastrointestinal hormone , gastric emptying , type 2 diabetes , cholecystokinin , diabetes mellitus , hormone , glucagon , peptide hormone , stomach , receptor
Seventeen non‐insulin‐dependent diabetics poorly controlled by diet and sulphonylurea drugs took part in a long‐term (20–52 weeks) trial of the effect of an alpha‐glucosidase inhibitor (acarbose 100 mg thrice daily) on postprandial glycaemic and gastro‐entero‐pancreatic hormone responses. Patients were assessed before, during, and after the trial period with identical 2.2 MJ mixed test meals plus placebo or acarbose 100 mg, and sulphonylurea therapy was continued throughout. Acarbose administration reduced the integrated postprandial plasma responses of glucose to 58 ± 10% (mean ± SEM, p < 0.001), insulin to 61 ± 10% ( p < 0.01) and gastric inhibitory polypeptide to 45 ± 8% ( p < 0.001) of control values, increased the enteroglucagon response to 152 ± 26% ( p < 0.001) of control and slightly prolonged the postprandial release of motilin. Recorded glycosuria was significantly ( p < 0.01) reduced throughout the treatment period. The effects of acarbose on postprandial glycaemic and endocrine responses remained approximately constant throughout the trial period, and responses returned to pre‐treatment values within 2 days of stopping treatment.