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Chlorpropamide Lowers Serum and Lipoprotein Cholesterol in Insulin‐Dependent Diabetes
Author(s) -
Seviour P. W.,
Teal T. K.,
Richmond W.,
Elkeles R. S.
Publication year - 1986
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1986.tb00727.x
Subject(s) - medicine , chlorpropamide , diabetes mellitus , endocrinology , insulin , cholesterol
Changes in serum lipids and lipoproteins were examined during eight weeks chlorpropamide therapy in eight C‐peptide negative, insulin‐dependent diabetic patients (mean age 40 years, mean onset of diabetes 20 years). Chloropropamide was found to have a generalized cholesterol lowering effect (progressive significant fall in mean total cholesterol, LDL‐C, HDL‐C, and HDL 3 ‐C) with no significant change in the ratio of high‐density lipoprotein to low‐density lipoprotein cholesterol which was independent of insulin secretion.