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Treatment of Diabetic Gastroparesis with Oral Domperidone
Author(s) -
Watts G. F.,
Armitage M.,
Sinclair J.,
Hill R. D.
Publication year - 1985
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1985.tb00689.x
Subject(s) - medicine , domperidone , gastroparesis , cisapride , diabetes mellitus , endocrinology , gastric emptying , stomach , dopamine
Three patients with severe diabetic gastroparesis unresponsive to metoclopramide were found to have markedly prolonged gastric half‐emptying times ( t 1/2 ) using a radionuclide‐labelled test meal. They all showed symptomatic improvement and normal t 1/2 within one week of taking oral domperidone 10 mg q.d.s. Oral domperidone may have a role in the treatment of severe diabetic gastroparesis particularly in metoclopramide‐resistant cases.