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Potentiation of Hypotensive Effect of Debrisoquine by Insulin
Author(s) -
Hume L.
Publication year - 1985
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1985.tb00659.x
Subject(s) - medicine , debrisoquine , insulin , long term potentiation , blood pressure , diabetes mellitus , anesthesia , endocrinology , metabolism , receptor , cyp2d6 , cytochrome p450
A 36‐year‐old man who had been an insulin‐dependent diabetic for 27 years developed severe postural hypotension only when taking debrisoquine and a short‐acting insulin. Hourly recordings of lying and standing blood pressure after an oral dose of debrisoquine in the presence and absence of short‐acting insulin confirmed an interaction between the drugs causing symptoms of postural hypotension which may be confused with hypoglycaemia.